When the medieval pilgrims arrived in Acquapendente, they visited the Basilica del Santo Sepulcro and there I discovered the Via Francigena sign.
During the Middle Ages, the original church was a popular destination for pilgrims, especially cripples, seeking miraculous cures. According to tradition, the church was founded by Queen Matilide of Westphalia (895-968). The Queen, headquartered in Rome, and her caravan of gold-laden mules set out for Acquapendente to build a sanctuary dedicated to the Holy Sepulcher. It was made a cathedral in 1649.